Tropical Journal of Pharmaceutical Research

Original Research Article | OPEN ACCESS

Effect of combined vitamin D and microwave ablation of parathyroid glands on blood pressure and cardiac function in maintenance-hemodialysis patients with uremic secondary hyperparathyroidism

Xinghua Zhu¹, Yingyu Li¹, Lu Chen¹, Chunli Du¹, Jingyuan Hou², Ailing Zhang¹, Baozhen Qiu¹, Jiaying Li¹

¹Hemopurification Center, Meizhou People’s Hospital, Meizhou 514031, China; ²Research and Experimental Centre, Meizhou People’s Hospital, Meizhou 514031, China.

For correspondence:- Jiaying Li Email: j7r4kx@163.com

Accepted: 19 June 2022 Published: 31 July 2022

Citation: Zhu X, Li Y, Chen L, Du C, Hou J, Zhang A, et al. Effect of combined vitamin D and microwave ablation of parathyroid glands on blood pressure and cardiac function in maintenance-hemodialysis patients with uremic secondary hyperparathyroidism. Trop J Pharm Res 2022; 21(7):1571-1577 doi: 10.4314/tjpr.v21i7.30

© 2022 The authors.
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Abstract

Purpose: To investigate the effect of microwave ablation of parathyroid glands in combination with active vitamin D on blood pressure and cardiac function in maintenance-hemodialysis patients with uremic secondary hyperparathyroidism.

Methods: One hundred and twenty maintenance-hemodialysis patients with uremic secondary hyperparathyroidism admitted to Meizhou People’s Hospital were assigned to 2 groups (A and B) in the order of their admission. Each group had 60 patients. Both groups were treated with active vitamin D, while patients in group A were, in addition, subjected to microwave ablation of parathyroid glands. Blood pressure, and indices for cardiac function, thyroid function s and anemia were determined.

Results: After treatment, the blood pressure of group A was significantly lower than that of group B (p < 0.05). Moreover, after treatment, there were significant improvements in indices of cardiac function, thyroid function and anemia in group A patients, relative to group B patients.

Conclusion: Microwave ablation of parathyroid glands, when combined with active vitamin D, improves blood pressure, cardiac function and anemia status. Furthermore, the combined therapy enhances recovery of thyroid function in maintenance-hemodialysis patients with uremic secondary hyperparathyroidism. However, the combined therapy should be subjected to further clinical trials prior to application in clinical practice.

Keywords: Microwave ablation, Parathyroid glands, Active vitamin D, Hyperparathyroidism